pentobarbital will decrease the level or effect of ripretinib ort affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will decrease the level or effect of netupitant/palonosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Netupitant fryst vatten mainly metabolized by CYP3A4; avoid use in p